abstract：:MicroRNAs (miRNAs) constitute a dominating class of small RNAs that regulate diverse cellular functions. Due the pivotal role of miRNAs in biological processes, a deregulated miRNA expression is likely involved in human cancers. MicroRNAs possess tumor suppressor capability, as well as display oncogenic characteristic...

journal_title：Anticancer research

authors： D'Angelo B,Benedetti E,Cimini A,Giordano A

更新日期：2016-11-01 00:00:00

abstract：:Four heart hormones, namely atrial natriuretic peptide (ANP), long-acting natriuretic peptide (LANP), vessel dilator and kaliuretic peptide reduce up to 97% of cancer cells in vitro. These four cardiac hormones eliminate up to 80% of human pancreatic adenocarcinomas, two-thirds of human breast carcinomas and up to 86%...

journal_title：Anticancer research

authors： Vesely DL

更新日期：2016-11-01 00:00:00

abstract：BACKGROUND:Dendritic cell (DC) mono-immunotherapy has not been successful so far in ovarian cancer. The addition of a toll-like receptor (TLR) agonist has the potential to boost the innate immune system, in addition to the adoptive immune response initiated by DCs. MATERIALS AND METHODS:ID8-fLuc C57BL/6 mice were inje...

journal_title：Anticancer research

authors： Vindevogel E,Baert T,VAN Hoylandt A,Verbist G,Vande Velde G,Garg AD,Agostinis P,Vergote I,Coosemans AN

更新日期：2016-11-01 00:00:00

abstract：AIM:To identify conditions that induce an increase in the sensitivity of highly Halaven (HAL)-resistant cancer cells compared to sensitive cells. MATERIALS AND METHODS:We observed that drug-resistant KBV20C cells are highly resistant to HAL compared to other antimitotic drugs. The concentration required to treat KBV20...

journal_title：Anticancer research

authors： Cheon JH,Lee BM,Kim HS,Yoon S

更新日期：2016-11-01 00:00:00

abstract：:Neutralizing single-domain antibodies directed towards catalase or superoxide dismutase (SOD) caused efficient reactivation of intercellular reactive oxygen species/reactive nitrogen species (ROS/RNS)-dependent apoptosis-inducing signaling specifically in human tumor cells. Single-domain antibodies targeted tumor cell...

journal_title：Anticancer research

authors： Bauer G,Motz M

更新日期：2016-11-01 00:00:00

abstract：:Norcantharidin (NCTD) was purified from mylabris, the dried body of the Chinese blister beetle. NCTD has been shown to exhibit anticancer activities in many human cancer cell lines, but there are no reports to show whether it induces apoptosis of human gastric cancer cells. Therefore, in the present study, we investig...

journal_title：Anticancer research

authors： Zheng LC,Yang MD,Kuo CL,Lin CH,Fan MJ,Chou YC,Lu HF,Huang WW,Peng SF,Chung JG

更新日期：2016-11-01 00:00:00

abstract：BACKGROUND:Polychlorinated biphenyls (PCBs) are ubiquitous environment-contaminating synthetic chemicals that have been associated with increased risk of hepatic cancer, melanoma, non-Hodgkin lymphoma and cancer of many other body organs. Structural binding analyses of PCB 77 and PCB 118 with peroxisome proliferator-ac...

journal_title：Anticancer research

authors： Sheikh IA,Khweek AA,Beg MA

更新日期：2016-11-01 00:00:00

abstract：BACKGROUND/AIM:The phosphatidylinositol-3-kinase (PI3K) signaling pathway is frequently activated in cancer. Buparlisib (BKM120), an oral pan-PI3K inhibitor, inhibits proliferation of human cancer in preclinical models. Studies of buparlisib in Western and Japanese adults with advanced solid tumors established a recomm...

journal_title：Anticancer research

authors： Wu YL,Zhang LI,Trandafir L,Dong T,Duval V,Hazell K,Xu B

更新日期：2016-11-01 00:00:00

abstract：BACKGROUND/AIM:Medullary thyroid cancer (MTC) is highly malignant, metastatic and recurrent, remaining generally incurable, and responsible for approximately 14% of all thyroid carcinoma-related deaths. MTC can metastasize to lymph nodes, trachea and distant organs, such as brain, lungs, liver and bones. MTC cells are ...

journal_title：Anticancer research

authors： Damaskos C,Garmpis N,Valsami S,Spartalis E,Antoniou EA,Tomos P,Karamaroudis S,Zoumpou T,Pergialiotis V,Stergios K,Michaelides C,Kontzoglou K,Perrea D,Nikiteas N,Dimitroulis D

更新日期：2016-10-01 00:00:00

abstract：BACKGROUND:Cancer stem cells (CSCs) are tumour-initiating cells with self-renewal properties and chemo/radio-resistance. Regulatory T-cells (Tregs) influence CSCs through several mechanisms. In different solid tumours, the presence of both cell populations correlated with poor survival. In vulvar cancer, little is know...

journal_title：Anticancer research

authors： Napoletano C,Bellati F,Ruscito I,Pernice M,Zizzari IG,Caponnetto S,Tomao F,Frigerio L,Liberati M,Rughetti A,Caserta D,Panici PB,Nuti M

更新日期：2016-10-01 00:00:00

abstract：BACKGROUND/AIM:FAM92A1-289 is recognized as one of the newly-discovered putative oncogenes. This study was performed to reveal its oncogenic functions in human cervical carcinoma cells. MATERIALS AND METHODS:The FAM92A1-289+ cell line was established with knock-in technique and selected by puromycin-resistance screeni...

journal_title：Anticancer research

authors： Gui H,Guo XR,Fang J,Ma SN,Wu G,Shen JH,Tu HJ,Li DS,Dai LJ,Ruan XZ

更新日期：2016-10-01 00:00:00

abstract：BACKGROUND:The rearrangement of actin cytoskeleton is being increasingly considered a marker of cancer cell activity, but the fine structure and remodeling of microfilaments within tumor tissue still remains unclear. MATERIALS AND METHODS:We used the recently introduced silicon-rhodamine (SiR)-actin dye to visualize e...

journal_title：Anticancer research

authors： Klementieva NV,Snopova LB,Prodanets NN,Furman OE,Dudenkova VV,Zagaynova EV,Lukyanov KA,Mishin AS

更新日期：2016-10-01 00:00:00

abstract：BACKGROUND:Women with recurrent ovarian cancer have a poor prognosis and short survival. However, some women are long-term survivors and it is unclear whether they share specific common characteristics. CASE REPORT:We present the case of a 63-year-old woman with histologically-proven recurrent ovarian cancer and a sur...

journal_title：Anticancer research

authors： Hilal Z,Schultheis B,Hartmann F,Dogan A,Cetin C,Krentel H,Schiermeier S,Tempfer CB

更新日期：2016-10-01 00:00:00

abstract：BACKGROUND:The purpose of this study was to examine the efficacy of anticoagulant fondaparinux postoperatively for preventing recurrence after curative resection of colorectal cancer with lymphnode metastasis. PATIENTS AND METHODS:The records of 279 patients who underwent curative resection of colorectal cancer with l...

journal_title：Anticancer research

authors： Yamaoka Y,Ikeda M,Ikenaga M,Murakami H,Haraguchi N,Miyake M,Yamamoto K,Asaoka T,Nishikawa K,Miyamoto A,Miyazaki M,Hirao M,Nakamori S,Sekimoto M

更新日期：2016-10-01 00:00:00

abstract：BACKGROUND/AIM:Minimal residual disease (MRD) in patients with acute myeloid leukemia (AML) before allogeneic hematopoietic stem cell transplantation (alloHSCT) can influence the results of therapy. With the aim of evaluating the potential role of pre-transplant MRD, we studied the impact of pre-transplant MRD level on...

journal_title：Anticancer research

authors： Karas M,Steinerova K,Lysak D,Hrabetova M,Jungova A,Sramek J,Jindra P,Polivka J,Holubec L

更新日期：2016-10-01 00:00:00

abstract：:Metastatic urothelial carcinoma is one of the most fatal urological malignancies. Cisplatin-based systemic chemotherapy is the standard treatment for metastatic urothelial carcinoma, and there is little evidence to support metastasectomy. The aims of the study were to evaluate the efficacy of metastasectomy and to inv...

journal_title：Anticancer research

authors： Iwamoto H,Izumi K,Shimura Y,Natsagdorj A,Maolake A,Takezawa Y,Nohara T,Shigehara K,Kadono Y,Mizokami A

更新日期：2016-10-01 00:00:00

abstract：BACKGROUND/AIM:Fluorescence-guided surgery (FGS) of cancer is an emerging technology. We have previously shown the importance of resecting both the tumor and the tumor microenvironment (TME) for curative FGS. We also previously developed a syngeneic model using the mouse lymphoma cell line EL-4, expressing red fluoresc...

journal_title：Anticancer research

authors： Hasegawa K,Suetsugu A,Nakamura M,Matsumoto T,Kunisada T,Shimizu M,Saji S,Moriwaki H,Bouvet M,Hoffman RM

更新日期：2016-09-01 00:00:00

abstract：BACKGROUND:Chronic lymphocytic leukemia (CLL) is characterized by a clonal accumulation of neoplastic lymphocytes, indicating disruption of apoptosis. PATIENTS AND METHODS:Differential methylation hybridization analysis was performed to identify novel target genes silenced by CpG island methylation in patients with CL...

journal_title：Anticancer research

authors： Schmidt-Wolf IG,Plass C,Byrd JC,Frevel K,Pietsch T,Waha A

更新日期：2016-09-01 00:00:00

abstract：BACKGROUND/AIM:Pressurized intraperitoneal aerosol chemotherapy (PIPAC) is a novel clinical approach to the treatment of peritoneal carcinomatosis. A well-established, not anatomic ex vivo PIPAC model was used to investigate the influence of changes in internal pressure, distance of the Micropump(©) (MIP) to the distri...

journal_title：Anticancer research

authors： Khosrawipour V,Khosrawipour T,Falkenstein TA,Diaz-Carballo D,Förster E,Osma A,Adamietz IA,Zieren J,Fakhrian K

更新日期：2016-09-01 00:00:00

abstract：BACKGROUND:The tumor microenvironment plays a critical role in tumor growth and spreading. Tumor-associated macrophages (TAM) make up a large proportion of the tumor mass and are one of the main producers of CC-chemokine ligand 18 (CCL18), which is believed to carry out important functions in the immunological interact...

journal_title：Anticancer research

authors： Schmid S,Le UT,Haager B,Mayer O,Dietrich I,Elze M,Kemna LJ,Zissel G,Passlick B

更新日期：2016-09-01 00:00:00

abstract：AIM:To evaluate whether the congested area that develops in associating liver partition with portal vein ligation for staged hepatectomy (ALPPS) contributes to rapid future liver remnant (FLR) hypertrophy. PATIENTS AND METHODS:Eight patients undergoing liver partition and right portal vein (RPV) ligation within the FL...

journal_title：Anticancer research

authors： Kawaguchi D,Hiroshima Y,Matsuo K,Endo I,Koda K,Tanaka K

更新日期：2016-09-01 00:00:00

abstract：BACKGROUND:Melanoma is among the top three cancers to present with brain metastasis. The risk of brain metastases in advanced melanoma increases with disease duration. Cytotoxic chemotherapy does not have a significant role in the management of melanoma patients with brain metastases, neither alone nor in conjunction w...

journal_title：Anticancer research

authors： Basnet A,Saad N,Benjamin S

更新日期：2016-09-01 00:00:00

abstract：BACKGROUND/AIM:Nodal staging is used in colorectal cancer (CRC) to determine which patients should receive adjuvant chemotherapy. The aim of this study was to evaluate the role of indocyanine green fluorescence imaging (ICG-FI) in sentinel lymph node (SLN) detection compared to the standard technique. MATERIALS AND ME...

journal_title：Anticancer research

authors： Liberale G,Vankerckhove S,Galdon MG,Larsimont D,Ahmed B,Bouazza F,Moreau M,El Nakadi I,Donckier V,Bourgeois P,R&D Group for the Clinical Application of Fluorescence Imaging at the Jules Bordet Institute.

更新日期：2016-09-01 00:00:00

abstract：BACKGROUND/AIM:We aimed to analyze the clinical impact of solid and micropapillary components in a series of Japanese patients resected for ≤3 cm lung adenocarcinoma. PATIENTS AND METHODS:A total of 115 patients with ≤3 cm lung adenocarcinomas were reviewed and classified according to the American Thoracic Society and...

journal_title：Anticancer research

authors： Matsuoka Y,Yurugi Y,Takagi Y,Wakahara M,Kubouchi Y,Sakabe T,Haruki T,Araki K,Taniguchi Y,Nakamura H,Umekita Y

更新日期：2016-09-01 00:00:00

abstract：:Medullary thyroid cancer (MTC) is a rare but aggressive thyroid malignancy. The gold-standard biomarker for its diagnosis and follow-up is calcitonin (CT); however, it has a variable half-life dependent on its circadian variability. It has been suggested that a more stable hormone, procalcitonin (PCT), may overcome th...

journal_title：Anticancer research

authors： Karagiannis AK,Girio-Fragkoulakis C,Nakouti T

更新日期：2016-08-01 00:00:00

abstract：BACKGROUND/AIM:Rhabdoid tumors (RT) are aggressive pediatric tumors, which show poor prognosis despite use of multimodal intensive therapy. In these tumors, several different oncogenic pathways and epigenetic regulators (like CDK4/6-cyclinD-Rb-signaling, EZH2, histone deacetylases) are contemporaneously deregulated as ...

journal_title：Anticancer research

authors： Moreno N,Kerl K

更新日期：2016-08-01 00:00:00

abstract：BACKGROUND/AIM:Alterations of global histone modification levels have been identified in various tumor entities, including bladder cancer (BCA). Our study was designed to investigate the value of global histone acetylation levels as diagnostic and prognostic biomarker for BCA patients. MATERIALS AND METHODS:A tissue m...

journal_title：Anticancer research

authors： Ellinger J,Schneider AC,Bachmann A,Kristiansen G,Müller SC,Rogenhofer S

更新日期：2016-08-01 00:00:00

abstract：AIM:The expression level of DNA repair-related genes and their association with breast cancer status among participants of the New York site of the Breast Cancer Family Registry was investigated. MATERIALS AND METHODS:RNA from mononuclear cells in 194 sister sets (n=475 women) were assayed for ATM, BRCA1, MSH2, MUTYH ...

journal_title：Anticancer research

authors： Kappil MA,Liao Y,Terry MB,Santella RM

更新日期：2016-08-01 00:00:00

abstract：AIM:This study assessed the symptoms and health-related quality of life (HRQOL) of patients with advanced non-small cell lung cancer (NSCLC) and examined the symptom-associated characteristics. PATIENTS AND METHODS:The symptoms of 122 patients with NSCLC scheduled for chemotherapy before starting treatment were survey...

journal_title：Anticancer research

authors： Silvoniemi M,Vasankari T,Löyttyniemi E,Valtonen M,Salminen E

更新日期：2016-08-01 00:00:00

abstract：AIM:To evaluate (18)F-fluorodihydroxyphenylalanine-positron emission tomography/ contrast-enhanced computed tomography ((18)F-DOPA PET/CT) for the detection of paragangliomas (PARA) without any patient selection, such as genetic predisposition for the development of these tumors, history of metastatic PARA or hormonal ...

journal_title：Anticancer research

authors： El-Rabadi K,Weber M,Mayerhofer M,Nakuz T,Scherer T,Mitterhauser M,Dudczak R,Hacker M,Karanikas G

更新日期：2016-08-01 00:00:00

abstract：AIM:We hypothesized that a nomogram can accurately predict overall survival (OS) for patients with intrahepatic cholangiocarcinoma (ICC) after hepatectomy. MATERIALS AND METHODS:A nomogram to predict OS based was developed using data from 185 ICC patients who had undergone hepatectomy. The nomogram was evaluated by co...

journal_title：Anticancer research

authors： Yeh CN,Wang SY,Chen YY,Chen MH,Chiang KC,Cheng CT,Tsai CY,Wang CC,Yeh TS,Chen TC

更新日期：2016-08-01 00:00:00

abstract：AIM:To assess the correlation between advanced non-small cell lung cancer (NSCLC) with or without pulmonary lymphangitic carcinomatosis (PLC) and fluorodeoxyglucose (FDG) uptake and its effect on survival outcomes. PATIENTS AND METHODS:We retrospectively reviewed 157 patients with NSCLC. The mean and maximum standardi...

journal_title：Anticancer research

authors： Ooi H,Chen CY,Hsiao YC,Huang WS,Hsieh BT

更新日期：2016-08-01 00:00:00

abstract：BACKGROUND:Complementary alternative medicine (CAM) is widely used among patients with cancer. This usage may have potentially harmful effects, especially when combined with anticancer drugs. However, some complementary methods may benefit patients. This review investigated the prevalence of CAM use among patients with...

journal_title：Anticancer research

authors： Nilsson J,Källman M,Östlund U,Holgersson G,Bergqvist M,Bergström S

更新日期：2016-07-01 00:00:00

abstract：BACKGROUND:MicroRNAs are able to control vital tumor biological processes, such as proliferation, tissue transformation and cell migration, as well as apoptosis. One of the micro RNAs, namely miR-1, has been classified as a tumor suppressor, however, preliminary data did not confirm this finding in ovarian cancer (OC) ...

journal_title：Anticancer research

authors： Stope MB,Hettenbach D,Kaul A,Paditz M,Diesing K,Burchardt M,Zygmunt M,Mustea A,Koensgen D

更新日期：2016-07-01 00:00:00

abstract：BACKGROUND:Programmed cell death ligand 1 (PD-L1) expression in lung cancer appears to be important in immunotherapy, as its expression can predict responses to programmed cell death-1 (PD-1)-blocking antibodies. However, a definitive antibody and cut-off value for PD-L1 expression are urgently needed. MATERIALS AND M...

journal_title：Anticancer research

authors： Takada K,Toyokawa G,Okamoto T,Akamine T,Takamori S,Katsura M,Fujishita T,Shoji F,Oda Y,Maehara Y

更新日期：2016-07-01 00:00:00

abstract：AIM:We report a retrospective evaluation for patients with stage IVB cervical cancer in order to identify survival rates and to improve our current practice. PATIENTS AND METHODS:We analyzed 85 patients with stage IVB cervical cancer. For patients appropriate for radical treatment, a combination of external-beam radio...

journal_title：Anticancer research

authors： Oishi S,Kudaka W,Toita T,Ariga T,Nakamoto T,Wakayama A,Nagai Y,Kaneshima I,Nishihira K,Aoki Y

更新日期：2016-07-01 00:00:00

abstract：AIM:The primary aim of the study was to assess the association between risk of recurrence and HER2 equivocal gene status through immunohistochemistry in patients with early breast cancer. PATIENTS AND METHODS:We retrospectively analyzed clinical and pathological data of 455 consecutive patients with early breast cance...

journal_title：Anticancer research

authors： Criscitiello C,Bagnardi V,Viale G,Disalvatore D,Rotmensz N,Esposito A,Goldhirsch A,Curigliano G

更新日期：2016-07-01 00:00:00

abstract：BACKGROUND/AIM:5-Aminolevulinic acid (5-ALA), a precursor of protoporphyrin IX (PpIX), is now used for photodynamic therapy (PDT) of pre-cancers of the skin and photodynamic diagnosis (PDD) of brain tumors. Sonodynamic therapy (SDT) of cancers with ultrasound has been studied using 5-ALA as a sonosensitizer. In this ar...

journal_title：Anticancer research

authors： Shimamura Y,Tamatani D,Kuniyasu S,Mizuki Y,Suzuki T,Katsura H,Yamada H,Endo Y,Osaki T,Ishizuka M,Tanaka T,Yamanaka N,Kurahashi T,Uto Y

更新日期：2016-07-01 00:00:00

abstract：BACKGROUND:Cancer stem cells (CSCs) have a high tumorigenic ability to form patient-derived tumor xenografts (PDXs). PDXs are an attractive pre-clinical model, but gene expression and biological behavior of cancer cells in the tumor will change during establishment and passage of PDXs. MATERIALS AND METHODS:Human colo...

journal_title：Anticancer research

authors： Mukohyama J,Shimono Y,Yamashita K,Sumi Y,Mukohara T,Minami H,Kakeji Y

更新日期：2016-07-01 00:00:00

abstract：BACKGROUND/AIM:The efficacy of omega-3 supplementation by oral capsule for patients with Crohn's disease (CD) remains controversial. We investigated the safety and efficacy of an omega-3 emulsified formulation. PATIENTS AND METHODS:Six patients with CD in remission participated in this open-label clinical trial. Patie...

journal_title：Anticancer research

authors： Yasueda A,Shinzaki S,Iijima H,Mizushima T,Nishimura J,Hiyama S,Ohno S,Ito T

更新日期：2016-07-01 00:00:00